Telomeric spindle proteins

Telomeric spindle proteins

elomeric proteins may have an unexpected connection to the mitotic spindle. On page 819, Xu and Blackburn provide evidence that the human homologue of a yeast telomere-binding protein is found on anaphase midzone microtubules. The telomeric functions of the human and yeast versions of this protein, Rif1, have diverged during evolution. In budding yeast, Rif1 is a telomere-bound negative regulat...

Telomeric Proteins

f Abstract Telomeres are essential for genome stability in all eukaryotes. Changes in telomere functions and the associated chromosomal abnormalities have been implicated in human aging and cancer. Telomeres are composed of repetitive sequences that can be maintained by telomerase, a complex containing a reverse transcriptase (hTERT in humans and Est2 in budding yeast), a template RNA (hTERC in...

Extra-Telomeric Roles of Telomeric Proteins

Differential Recruitment of Telomeric Proteins

www.sciencemag.org (this information is current as of March 16, 2008 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/319/5866/1092 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/1151804/DC1 can be found at: ...

G-proteins for spindle geometry

kinetochore protein plays both sides of the checkpoint field, according to Weaver et al. on page 551. They show that CENP-E, a mitotic checkpoint-silencing protein, also stimulates the amount of checkpoint inhibitor released from an unattached kinetochore. The mitotic checkpoint is the major mechanism preventing chromosomal loss during mammalian mitosis. Unattached kinetochores generate an inhi...